The MTX or Methotrexate side effects are beginning! This past week we had increased to MTX to 17.5 MG'S. We noticed Saturday this time, that Jacob seemed to have lost his appetite. He did not eat too much all day. He confessed to me later in the day that he had a stomach ache. By Sunday he started complaining that had a canker sore in his mouth. I did notice one inside his bottom lip. Monday he was starting to complain even more about his mouth. By today, Tuesday night he was really in a lot of pain. I was able to see he had a least 3 ulcerations in his mouth. I paged the rheumatologist and he said he was going to call in folic acid in the morning which should clear up the ulcers in a couple of days. Jacob is so frustrated with everything going on this week. His knee, especially today, has been really bothersome. It doesn't look as swollen as it did but it seems to be more painful. Tonight he even tripped and fell right on his knee! That didn't help matters! One more week and 2 days until the consult with the orthopedic doctor. I can't wait to see what he has to say about the MRI. I just want something done so Jake can start the healing process. It is just so upsetting to see him in so much pain.